Martina Bremer

Martina BremerProfessor

Statistics, Biostatistics
408-924-1396
martina.bremer@sjsu.edu
MH 318A

Research Areas

  • Statistics
  • Bioinformatics

Biography

I am a statistician with an interest in bioinformatics. In particular, I am interested in the analysis and interpretation of microarray data. DNA Microarrays (or gene chips) exist for many organisms - animals, plants, and humans. They are used to measure the extent to which many genes (humans have about 30,000 protein coding genes) are β€œturned on” at any given time. Researchers are interested in measuring gene expression to study which genes are associated with a particular condition such as cancer.

Genes are influenced by many things: external factors that an organism is subjected to (e.g., drought for plants or disease for humans) but genes and proteins also influence each other in a complicated network. Is it possible to identify genes that are up or down regulated by other genes or by proteins in time course microarray data? This question is investigated using a state space model for gene regulation in my .

Publications

  • Harsh Bhatia, Attila G. Gyulassy, Valerio Pascucci, Martina Bremer, Mitchell T. Ong, Vincenzo Lordi, Erik W. Draeger, John E. Pask, and Peer-Timo Bremer. . In Proceedings of the 9th IEEE Pacific Visualization Symposium, pp. 120–127, Taipei, Taiwan. Apr. 19–22, 2016.
  • M. Bremer, R.W. Doerge,  Cold Spring Harbor Press, 2015.
  • T. Nguyen, D. Ravindra, B. Kwong, S. Waheed, N. Tarlton, R. Ferguson, M. Bremer, T. Abramson,  PLOS One, December 2012, Vol 7, Issue 12.
  • S. Yadegarnynia, A. Pham, A. Ng, D. Nguyen, T. Lialiutska, A. Bortolazzo, V. Syvriuk, M. Bremer, J.B. White,  Natural Product Communications, 7 (10), 2012.
  • N.J. Tarlton, C.M. Green, N.H. Lazarus, L. Rott, A.P. Wong, O.N. Abramson, M. Bremer, E.C. Butcher, T. Abramson, , April 5, 2012.
  • J. Park, P.L. Knezevich, W. Wung, S.N. O’Hanlon, A. Goyal, K.L. Benedetti, B.J. Barsi-Rhyne, M. Raman, N. Mock, M. Bremer, M.K. VanHoeven, , Neural Development, 6:28, 2011.
  • A.Madlung, M. Bremer, E. Himelblau, A. Tullis, , CBE - Life Sciences Education, Vol 10, 43 - 54, Spring 2011.
  • M. Bremer & R.W. Doerge, , Cold Spring Harbor Press, 2010
  • M. Bremer, E. Himelblau, A. Madlung,  (book chapter) in Bang, H, Zhou, XK, Van Epps, H, Mazumdar, M. (Editors) Statistical Methods in Molecular Biology. Humana Press. 2010.
  • M. Bremer & R.W. Doerge, , Advances in Bioinformatics, 2009